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Medicinal Chemistry, 2nd Edition by P. Yogeeswari, D. Sriram

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Chapter 27

Antitubercular Agents

LEARNING OBJECTIVES
  • Define tuberculosis, its causes, and the treatment options

  • Describe the chemistry, mode of action, and utility of first-line treatment option for tuberculosis

  • Brief the utility of fluoroquinolones as antituberculers

27.1 INTRODUCTION

Tuberculosis is the most prevalent infectious disease worldwide and a leading killer caused by a single infectious agent, i.e., Mycobacterium tuberculosis. According to a WHO report, M. tuberculosis currently infects over two billion people worldwide, with some 30 million new cases reported every year. This intracellular infection accounts for at least three million deaths annually. Common infection sites of tuberculosis are lungs (primary site), brain, ...

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