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Medicinal Chemistry, 2nd Edition by P. Yogeeswari, D. Sriram

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Chapter 15

Diuretics

LEARNING OBJECTIVES
  • Define diuretics and their action in various regions of the urinary system

  • Classify diuretics and explain their mode of action

  • Describe the importance of structural modification with respect to diuretic potential

  • Describe various synthetic modes for the preparation of thiazide diuretics

  • Describe the synthesis, utility, and duration of action of various diuretics

15.1 INTRODUCTION

Diuretics are chemicals that increase secretion of excess water and salt that accumulate in tissues and urine. An excess quantity of intercellular fluid is formed in the organism as a result of an inability of the kidneys to release sodium ions fast enough to ensure that a sufficient quantity of water is excreted along ...

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