May 2010
Intermediate to advanced
712 pages
18h 30m
English
Content preview from Medicinal Chemistry, 2nd Edition
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Chapter 15
Diuretics
LEARNING OBJECTIVES
Define diuretics and their action in various regions of the urinary system
Classify diuretics and explain their mode of action
Describe the importance of structural modification with respect to diuretic potential
Describe various synthetic modes for the preparation of thiazide diuretics
Describe the synthesis, utility, and duration of action of various diuretics
15.1 INTRODUCTION
Diuretics are chemicals that increase secretion of excess water and salt that accumulate in tissues and urine. An excess quantity of intercellular fluid is formed in the organism as a result of an inability of the kidneys to release sodium ions fast enough to ensure that a sufficient quantity of water is excreted along ...
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