Chapter 24

Sulphonamides, Sulphones, and Dihydrofolate Reductase Inhibitors

LEARNING OBJECTIVES
  • Define sulphonamides and their utility as chemotherapeutic agents

  • Categorize and describe the mechanism of action of sulphonamides

  • Describe the side-effects and structural requirement of sulphonamides

  • Explain the synthetic protocol of sulpha drugs

  • Define sulphones and their utility

  • Describe the function of DHFR and its inhibitors

  • List some new DHFR inhibitors

The sulphonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. The sulphonamides and sulphone antibacterials as well as the 2,4-diaminopyrimidine antifolates continue to be successful chemotherapeutic agents. ...

Get Medicinal Chemistry, 2nd Edition now with O’Reilly online learning.

O’Reilly members experience live online training, plus books, videos, and digital content from 200+ publishers.