Chapter 24

Sulphonamides, Sulphones, and Dihydrofolate Reductase Inhibitors

  • Define sulphonamides and their utility as chemotherapeutic agents

  • Categorize and describe the mechanism of action of sulphonamides

  • Describe the side-effects and structural requirement of sulphonamides

  • Explain the synthetic protocol of sulpha drugs

  • Define sulphones and their utility

  • Describe the function of DHFR and its inhibitors

  • List some new DHFR inhibitors

The sulphonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. The sulphonamides and sulphone antibacterials as well as the 2,4-diaminopyrimidine antifolates continue to be successful chemotherapeutic agents. ...

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