May 2010
Intermediate to advanced
712 pages
18h 30m
English
Content preview from Medicinal Chemistry, 2nd Edition
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Chapter 24
Sulphonamides, Sulphones, and Dihydrofolate Reductase Inhibitors
LEARNING OBJECTIVES
Define sulphonamides and their utility as chemotherapeutic agents
Categorize and describe the mechanism of action of sulphonamides
Describe the side-effects and structural requirement of sulphonamides
Explain the synthetic protocol of sulpha drugs
Define sulphones and their utility
Describe the function of DHFR and its inhibitors
List some new DHFR inhibitors
The sulphonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. The sulphonamides and sulphone antibacterials as well as the 2,4-diaminopyrimidine antifolates continue to be successful chemotherapeutic agents. ...
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