May 2010
Intermediate to advanced
712 pages
18h 30m
English
Content preview from Medicinal Chemistry, 2nd Edition
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Chapter 25
Quinolone Antibacterials
Define quinolones and the structural aspects
Describe the mode of action and classify quinolones on the basis of treatment options
Explain the structural modification of quinolones and their effect on biological functions
Derive the synthetic routes for various fluoroquinolones
List some newer quinolones
25.1 INTRODUCTION
Quinolones constitute a large class of synthetic antimicrobial agents that are highly effective in the treatment of many types of infectious diseases, particularly those caused by bacteria. Quinolones are potent, broad-spectrum antibacterial agents. The early congeners (non-fluorinated at C-6 like nalidixic acid) were limited to certain gram-negative infections such as urinary tract infections. ...
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