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Medicinal Chemistry, 2nd Edition by P. Yogeeswari, D. Sriram

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Chapter 25

Quinolone Antibacterials

  • Define quinolones and the structural aspects

  • Describe the mode of action and classify quinolones on the basis of treatment options

  • Explain the structural modification of quinolones and their effect on biological functions

  • Derive the synthetic routes for various fluoroquinolones

  • List some newer quinolones

25.1 INTRODUCTION

Quinolones constitute a large class of synthetic antimicrobial agents that are highly effective in the treatment of many types of infectious diseases, particularly those caused by bacteria. Quinolones are potent, broad-spectrum antibacterial agents. The early congeners (non-fluorinated at C-6 like nalidixic acid) were limited to certain gram-negative infections such as urinary tract infections. ...

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