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Medicinal Chemistry, 2nd Edition by P. Yogeeswari, D. Sriram

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Chapter 8

Anti-Epileptic Drugs

LEARNING OBJECTIVES
  • Define epilepsy and the causes of the disorder

  • Categorize various forms of the disorder

  • Categorize the anticonvulsant drugs based on the chemical class

  • Learn the basic structural composition for a molecule to act as anticonvulsants

  • Define pharmacophore model and how it can be derived

  • Categorize anticonvulsants on the basis of treatment of different seizure types

  • Define GABA and the importance of developing its analogues

  • Describe some newer anticonvulsants

8.1 INTRODUCTION: EPILEPSY AND TYPES OF SEIZURES

Epilepsy is a brain disorder in which clusters of nerve cells, or neurons, in the brain sometimes signal abnormally. In epilepsy, the normal pattern of neuronal activity becomes disturbed, ...

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