May 2010
Intermediate to advanced
712 pages
18h 30m
English
Content preview from Medicinal Chemistry, 2nd Edition
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Chapter 23
Cholinergic Drugs
LEARNING OBJECTIVES
Define acetyl choline and cholinergic receptors
Describe the actions and uses of cholinomimetics
Describe the structural requirements for cholinergic agonist
Define acetylcholinesterase and the utility of inhibitors
Define antimuscarinics and classify based on structure
Compare the tertiary and quarternary amines as antimuscarinics
List the newer drugs in the class of cholinergic agents
23.1 INTRODUCTION
Cholinergic nerves (parasympathetic nerves) are found in the peripheral and the central nervous system of humans. Cholinergic neurons synthesise, store, and release acetylcholine (ACh). Acetylcholine is prepared at the nerve ending by the transfer of an acetyl group from acetyl-CoA to choline. ...
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I'm always learning. So when I got on to O'Reilly, I was like a kid in a candy store. There are playlists. There are answers. There's on-demand training. It's worth its weight in gold, in terms of what it allows me to do.