February 2007
Beginner to intermediate
464 pages
16h
English
book
Pharmaceutical Statistics Using SAS
by Ph. D. Alex Dmitrienko, Ph. D. Christy Chuang-Stein, Sr. Ralph B. D'Agostino
Content preview from Pharmaceutical Statistics Using SAS
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Chapter 9. Allocation in Randomized Clinical Trials
Olga Kuznetsova[]
[] Olga Kuznetsova is Associate Director, Clinical Biostatistics, Merck, USA.
Anastasia Ivanova[]
[] Anastasia Ivanova is Associate Professor, Department of Biostatistics, University of North Carolina-Chapel Hill, USA.
This chapter discusses the operationla aspects of randomization designs used in the pharmaceutical industry. Most of this chapter is devoted to the widely used permuted block design and its variations. Allocation procedures that balanced on baseline covariates, such as stratified randomization and covariate-adaptive randomization are also described. All methods are illustrated by examples that include SAS code to generate allocation sequences. Although all of ...
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