February 2007
Beginner to intermediate
464 pages
16h
English
book
Pharmaceutical Statistics Using SAS
by Ph. D. Alex Dmitrienko, Ph. D. Christy Chuang-Stein, Sr. Ralph B. D'Agostino
Content preview from Pharmaceutical Statistics Using SAS
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7.5. Models with a Bounded Response (Beta Models
The beta regression model provides another example where the information matrix can be calculated in a closed form.
7.5.1. General Model
In clinical trials, investigators often need to deal with ordinal variables containing many categories. The Beta regression model has been shown to be a good choice to analyze this type of response; see Wu, Fedorov and Propert (2005).
Figure 7-6. Left panel: Initial (open circles) and optimal (closed circles) designs. Right panel: Sensitivity functions for the initial (dashed curve) and optimal (solid curve) designs.
In this section we consider an example from ...
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