February 2007
Beginner to intermediate
464 pages
16h
English
book
Pharmaceutical Statistics Using SAS
by Ph. D. Alex Dmitrienko, Ph. D. Christy Chuang-Stein, Sr. Ralph B. D'Agostino
Content preview from Pharmaceutical Statistics Using SAS
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12.8. Sensitivity Analysis
Sensitivity to model assumptions has been reported for about two decades (Verbeke and Molenberghs, 2000; Molenberghs and Verbeke, 2005). In an attempt to formulate an answer to these concerns, a number of authors have proposed strategies to study sensitivity.
Broadly, we could define a sensitivity analysis as one in which several statistical models are considered simultaneously and/or where a statistical model is further scrutinized using specialized tools (such as diagnostic measures). This rather loose and very general definition encompasses a wide variety of useful approaches. The simplest procedure is to fit a selected number of (MNAR) models which are all deemed plausible or to fit one model in which a preferred ...
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