February 2007
Beginner to intermediate
464 pages
16h
English
book
Pharmaceutical Statistics Using SAS
by Ph. D. Alex Dmitrienko, Ph. D. Christy Chuang-Stein, Sr. Ralph B. D'Agostino
Content preview from Pharmaceutical Statistics Using SAS
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7.3. Nonlinear Regression Models with a Continuous Response
In this section we first formulate the optimal design problem for general nonlinear regression models and then consider a popular dose-response model with a continuous response variable (four-parameter logistic, or Emax, model).
7.3.1. General Nonlinear Regression Model
Consider a general nonlinear regression model that is used in the analysis of concentration- or dose-response curves in a large number of clinical and pre-clinical studies. The model describes the relationship between a continuous response variable, Y, and design variable x (dose or concentration level):
Here yij's ...
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