February 2007
Beginner to intermediate
464 pages
16h
English
book
Pharmaceutical Statistics Using SAS
by Ph. D. Alex Dmitrienko, Ph. D. Christy Chuang-Stein, Sr. Ralph B. D'Agostino
Content preview from Pharmaceutical Statistics Using SAS
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12.4. Simple Methods and MCAR
We will briefly review a number of relatively simple methods that have been and are still in extensive use. They have been discussed in some detail in Dmitrienko et al. (2005, Chapter 5). We will focus on complete case analysis (CC) and last observation carried forward (LOCF). The latter is a single or simple imputation method, which shares a certain number of pitfalls with the other methods. Multiple imputation, on the other hand (Section 12.5.2) is valid under MAR and therefore is discussed in Section 12.5.
12.4.1.
12.4.1.1. Complete Case Analysis
A complete case (CC) analysis considers only those cases for which all ni measurements were recorded. The method is simple since it restores balance, in the sense ...
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