February 2007
Beginner to intermediate
464 pages
16h
English
book
Pharmaceutical Statistics Using SAS
by Ph. D. Alex Dmitrienko, Ph. D. Christy Chuang-Stein, Sr. Ralph B. D'Agostino
Content preview from Pharmaceutical Statistics Using SAS
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7.9. Models with Cost Constraints
Traditionally, when normalized designs are discussed, the normalization factor is equal to the number of experiments N; see (7.3). In this section we will consider cost-normalized designs. Each measurement at point Xi is assumed to be associated with a cost c(Xi) and a restriction on the total cost is given by
In this case it is quite natural to normalize the information matrix by the total cost C and introduce
Once the cost function c(X) is defined, we can introduce a cost-based design ξC = {wi,Xi and use exactly ...
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