February 2007
Beginner to intermediate
464 pages
16h
English
book
Pharmaceutical Statistics Using SAS
by Ph. D. Alex Dmitrienko, Ph. D. Christy Chuang-Stein, Sr. Ralph B. D'Agostino
Content preview from Pharmaceutical Statistics Using SAS
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9.2. Permuted Block Randomization
Permuted block randomization is commonly used in clinical trials to allocate subjects to the treatment arms in required ratios. It is well accepted in the clinical community, provides good balance in treatment assignments, and supports the needs of drug packaging and distribution.
9.2.1. Permuted Block Designs
The permuted block schedule consists of a sequence of blocks that contain the treatment assignments in desired ratios; the treatment assignments are randomly permuted within the blocks. Consider, for example, a study in which subjects are to be assigned to three treatments (Treatment 1, Treatment 2 and Treatment 3) using a 2:2:1 ratio. The smallest permuted block that provides the 2:2:1 treatment ratio ...
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