Pharmaceutical Statistics Using SAS
by Ph. D. Alex Dmitrienko, Ph. D. Christy Chuang-Stein, Sr. Ralph B. D'Agostino
3.2. Example: Solubility Data
Solubility is an important physical-chemical property in drug discovery. In the simplest definition, the solubility of a solute is the maximum amount of the solute that can dissolve in a certain amount of solvent. Intrinsic solubility is the solubility of the neutral form of the salt; the salt has not separated into ions. Some of the factors affecting solubility are: temperature, molecular weight, number of hydrogen bonds, polarity.
For a solvent to dissolve a solute, particles of the solvent must be able to separate the particles of the solute and occupy the intervening spaces. Water is a polar substance and polar solvents can generally dissolve solutes that are ionic. Dissolving takes place when the solvent is ...
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