February 2007
Beginner to intermediate
464 pages
16h
English
book
Pharmaceutical Statistics Using SAS
by Ph. D. Alex Dmitrienko, Ph. D. Christy Chuang-Stein, Sr. Ralph B. D'Agostino
Content preview from Pharmaceutical Statistics Using SAS
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7.10. Summary
Design optimization is a critical aspect of experimentation; this is particularly true in pharmaceutical applications. There are many barriers to routine application of optimal design theory. Among these is the lack of software. For the mathematically simplest cases, namely linear models where the parameters are independent of the variance function, many software packages are available for finding optimal designs (see Section 7.1.6). However, as models increase in complexity, the availability of software for solving optimal design problems drops off dramatically and pharmaceutical researchers often find it frustrating. Some academic labs have created software that supports selected optimal designs (see Section 7.1.6) but a general ...
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