February 2007
Beginner to intermediate
464 pages
16h
English
book
Pharmaceutical Statistics Using SAS
by Ph. D. Alex Dmitrienko, Ph. D. Christy Chuang-Stein, Sr. Ralph B. D'Agostino
Content preview from Pharmaceutical Statistics Using SAS
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8.1. Introduction
When a tablet of drug is taken orally, in general, it reaches the stomach and begins to disintegrate and is absorbed (A). When dissolved into solution in the stomach acid, the drug is passed on to the small intestine (Rowland and Tozer, 1980). At this point, some of the drug will pass through and be eliminated (E) from the body. Some will be metabolized (M) into a different substance in the intestine, and some drug will be picked up by the walls of the intestine and distributed (D) into the body. This last bit of drug substance passes through the liver first, where it is also often metabolized (M). The drug substance that remains then passes through the liver and reaches the bloodstream, where it is circulated throughout the ...
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