February 2007
Beginner to intermediate
464 pages
16h
English
book
Pharmaceutical Statistics Using SAS
by Ph. D. Alex Dmitrienko, Ph. D. Christy Chuang-Stein, Sr. Ralph B. D'Agostino
Content preview from Pharmaceutical Statistics Using SAS
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10.3. p-Values, α, β and Power
The primary efficacy analysis will yield a p-value that compares the mortality rates of control versus QCA. Smaller p-values indicate greater statistical separation between the two samples, but how that p-value is determined is an issue that is not critical to understanding the essential concepts in sample-size analysis. In this case, that p-value may come from one of the many methods to compare two independent proportions, including the likelihood ratio chi-square test, as used here, or it may come from a logistic or hazard modeling that includes co-predictors. Regardless of what test is used to get the p-value, if p is small enough ("significant") and the QCA mortality rates are better, Dr. Capote will report ...
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