April 2022
Beginner to intermediate
486 pages
10h 22m
Chinese
Content preview from 云端基因组学
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在
Terra
平台快捷运行多个工作流
｜
341
该例中，工作流的所有任务调用都匹配调用缓存；换言之，调用已被缓存（英文为
call-cached
，这个单词可用作动词），因此实际上除了
Cromwell
服务器自己执行几
个文件复制操作之外，它并未运行任何代码。你若修改
MergeVCFs
调用，即使只作
少许修改，再次运行工作流，
HaplotypeCaller
调用仍命中缓存，但
MergeVCFs
却不会，
因此
Cromwell
会将该调用交
PAPI
执行。你可以修改
MergeVCFs
使用的容器镜像版
本（试试
4.1.4.1
），并再次运行，稍后再查看计时图确认该任务是否执行。
取消工作流配置部分的相关复选框，就可以禁用缓存调用，但为何要这么做？
调用缓存功能很强大，使用该功能就好像在哗哗赚钱！（因为它帮你节省很
多钱。）省钱就是赚钱，这是天下的爸爸们爱讲的话。
好吧，该休息了。你感觉如何？读到这里你有点迷茫，这再正常不过；毕竟你刚获
得这种超能量。我们认真告诉你，你现在有能力在你可获取的多个样本上运行真实、
复杂的基因组工作流。这个成就可不小。俗话说，布丁好不好吃，只有吃了才知道，
因此请拿把勺子，来口大的。
11.3
运行一个真实、全规模
GATK
最佳实践
流水线
你还记得第
9
章的神秘工作流
2
吗？它其实是博德研究所的全基因组分析流水线。
它大概不是世界上最大的基因组流水线（尽管它非常大），它也不是世界上最快的
流水线（因为它需要保持低价）。但它可能是基因组史上处理最大量人类全基因组
样本的流水线（目前为止）。倘若你打算学习如何以非常标准的方式开展某些工作， ...
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O’Reilly covers everything we've got, with content to help us build a world-class technology community, upgrade the capabilities and competencies of our teams, and improve overall team performance as well as their engagement.Julian F.
I wanted to learn C and C++, but it didn't click for me until I picked up an O'Reilly book. When I went on the O’Reilly platform, I was astonished to find all the books there, plus live events and sandboxes so you could play around with the technology.Addison B.
I’ve been on the O’Reilly platform for more than eight years. I use a couple of learning platforms, but I'm on O'Reilly more than anybody else. When you're there, you start learning. I'm never disappointed.Amir M.
I'm always learning. So when I got on to O'Reilly, I was like a kid in a candy store. There are playlists. There are answers. There's on-demand training. It's worth its weight in gold, in terms of what it allows me to do.