April 2022
Beginner to intermediate
486 pages
10h 22m
Chinese
Content preview from 云端基因组学
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在
Terra
平台自己组装工作区
｜
419
无法在原地编辑列名或删除不想要的列，这确实有点烦。导入对话框也有局
限，例如，确认执行导入操作之前，我们喜欢预览数据以了解数据有几行几
列。我们希望随着
Terra
平台走向成熟，其界面在这些方面能有所改善。
令人欣慰的是我们只要编辑两个列名，就能解决命名不匹配这个小问题。虽然这似
乎是个小问题，但是这个坎其实是一更大问题的症状：数据集的组织方式及其属性
的命名方式，其标准化工作还不到位。尝试分析源头不同的联合数据集，几乎都会
快速变成一项折磨人的练习，因为你得解决数据模式和命名规范方面的冲突。然而，
目前这方面还没有统一解决方案。当你遇到这种问题，先化简问题，将其限定到需
调和组件的最小集合，将非常有帮助。例如，尝试定义每个数据集的核心数据模式，
即确定数据的关键部分，理清各部分之间的关系。调整数据，提高其兼容程度，以
满足工作需要，具体要做哪些工作呢？你可据此评估。
该例中，我们已拿到我们需要的数据表：我们的所有样本都在
sample
表定义，其中
GVCF
文件放在
gvcf
列，对应的索引文件放在
gvcf_index
列。表中其他列与我们接
下来要做的无关。下面我们对工作区所有样本执行联合变异识别分析。
13.3.6
对联合数据集执行联合识别分析
为结束场景三，我们将运行该工作区预先配置好的
3_Joint_Discovery
工作流。如第
6
章所讲它采用
GATK
最佳实践，在一组样本上联合识别种系短变异。我们先在一
部分样本上试运行工作流，但我们将提供其扩展说明，如想在所有样本上运行 ...
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O’Reilly covers everything we've got, with content to help us build a world-class technology community, upgrade the capabilities and competencies of our teams, and improve overall team performance as well as their engagement.Julian F.
I wanted to learn C and C++, but it didn't click for me until I picked up an O'Reilly book. When I went on the O’Reilly platform, I was astonished to find all the books there, plus live events and sandboxes so you could play around with the technology.Addison B.
I’ve been on the O’Reilly platform for more than eight years. I use a couple of learning platforms, but I'm on O'Reilly more than anybody else. When you're there, you start learning. I'm never disappointed.Amir M.
I'm always learning. So when I got on to O'Reilly, I was like a kid in a candy store. There are playlists. There are answers. There's on-demand training. It's worth its weight in gold, in terms of what it allows me to do.