April 2022
Beginner to intermediate
486 pages
10h 22m
Chinese
Content preview from 云端基因组学
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344
｜
第
11
章
另一方面，
participant
（受试）表你可能没见过。它列出所有受试，尽管该例只有一
个人。如仔细看
sample
表，你也许已注意到其中一列为
participant
，这是一个标识词，
它指向受试表的一个条目（受试表中的
participant_id
）。受试表的目的是为数据提
供一种更高层级的组织方式，如有多位受试，其作用就会显现，并且每位受试可有
多个与之相关联的样本，每个样本对应不同数据类型、不同测定结果，或两者均可能。
完成这步之后，你就可以用数据表系统去做一些事情，比如在一组受试的所有样本
上运行一个工作流。
再举一例，
Mutect2
体细胞分析流水线（详见第
7
章）期望接受每位病人的一个肿
瘤样本和与之匹配的正常样本（其正式名称为样本对）。你若查看对应的
GATK
最
佳实践工作区（写作本书时为这一个：
https://oreil.ly/a8ksp
），将看到它用四个数
据表组织数据，将数据划分为受试、样本、样本对和样本集合（
PoN
使用的正常样本，
详见第
7
章）。该工作区的数据表遵从
TCGA
癌症研究计划“
The Cancer Genome
Atlas
”（癌症基因组图谱）所定义的数据模式。
更一般地讲，你可以用任意数量的数据表组织数据，并用一种结构化数据模式描述
受试、样本和其他数据实体之间的关系。第
13
章，我们将讨论在
Terra
中构建数据
模式的几种方法及其用法。这些方法使用得当，既省钱又省功夫。
11.3.3
选数据并配置全规模工作流
如前所述，你既可以直接到工作区的工作流页面，也可从“
Data ...
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I'm always learning. So when I got on to O'Reilly, I was like a kid in a candy store. There are playlists. There are answers. There's on-demand training. It's worth its weight in gold, in terms of what it allows me to do.