April 2022
Beginner to intermediate
486 pages
10h 22m
Chinese
Content preview from 云端基因组学
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434
｜
第
14
章
我们着手准备这部分内容时，曾预料到某些关键挑战可能会影响基因组研究文献的
作者和读者，而我们清楚绝大部分挑战的解决方案。因而，我们的主要目标是突出
这些已知挑战的实际表现，并介绍在实际工作中该如何克服它们。我们采用开放科
学运动中专家所建议使用的方法和理论。接着本着推广一组最佳实践的终极目标开
发教学材料，期望研究者可采用这些行之有效的实践，发布其工作成果。
我们综合考虑一系列条件（稍后介绍）之后，选择研究一种先天性心脏病的遗传危
险因素，并跟论文主要作者之一
Matthieu J. Miossec
博士合作，复现了论文核心部
分的计算分析过程（可以这么说）。项目过程中，我们证实了我们的一些假设，但
也遇到我们未曾料到的障碍。因此，我们得到了比预期要多得多的教训，而这并不
是一位研究者所能想象到的最糟结果。
本章第一节先铺陈舞台背景，讨论我们决策依据的原理；该节接着介绍我们打算复
现的案例研究，充实舞台布景。期间，我们讨论本章伊始所界定的那个挑战，并介
绍使用什么逻辑解决它们。该节最后，概括介绍我们的实现方案，它是后续小节深
入研究该方案的前奏，届时我们将研究该项目每个阶段的重要细节。
注
1
14.1.1
计算可复现和
FAIR
框架
在我们深入研究力求复现的分析细节之前，有必要重申术语“可复现”
（
reproducibility
）的含义并确保我们将其跟“可重现”（
replication
）区分开。我
们之前见过这两个术语的不同用法，它们有时可换着用，而就其正确用法，我们还
不清楚有没有达成任何共识。因此 ...
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O’Reilly covers everything we've got, with content to help us build a world-class technology community, upgrade the capabilities and competencies of our teams, and improve overall team performance as well as their engagement.Julian F.
I wanted to learn C and C++, but it didn't click for me until I picked up an O'Reilly book. When I went on the O’Reilly platform, I was astonished to find all the books there, plus live events and sandboxes so you could play around with the technology.Addison B.
I’ve been on the O’Reilly platform for more than eight years. I use a couple of learning platforms, but I'm on O'Reilly more than anybody else. When you're there, you start learning. I'm never disappointed.Amir M.
I'm always learning. So when I got on to O'Reilly, I was like a kid in a candy store. There are playlists. There are answers. There's on-demand training. It's worth its weight in gold, in terms of what it allows me to do.