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Process Control: Modeling, Design, and Simulation by B. Wayne Bequette

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M12.1. Overview

Physiological systems are composed of a large number of feedback control loops. Examples include the baroreceptor reflex that regulates blood pressure, and the synthesis of insulin and glucagon by the pancreas to regulate blood glucose. The focus of the examples presented in this module is on exogenous feedback regulation using devices external to the human body.

There is a rich history of automated control applications in biomedicine. Initial studies on feedback control of anesthesia were performed by Bickford at the Mayo Clinic in the 1950s. Several different anesthetics were studied as the manipulated input, while the measured variable was the integrated rectified amplitude of the EEG. The control strategy did not gain acceptance ...

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