Handbook of Biomedical Optics

Optical and Opto-Acoustic Molecular Tomography 453

dierent forms of functions can be constructed for minimiza-

tion (Gibson et al. 2005). Minimization of (22.10) or (22.11) can

be performed using conjugate gradient methods.

22.4.3 Use of Priors

While the above steps illustrate methods for stand-alone uo-

rescence tomography, signicant improvements in the imag-

ing performance come from the utilization of high-resolution

image data that are co-registered with the optical measurements

and can be used for improving the accuracy of the inversion

by reducing the ill-posed nature of the inverse problem and

for allowing for the construction of ...