
364 Handbook of Biomedical Optics
valid for LOT data, and Monte Carlo modeling is typically too
slow for implementation within iterative nonlinear reconstruc-
tions. Furthermore, to date, LOT has only been implemented for
continuous wave (CW) measurements, which in general cannot
accurately distinguish between the eects of absorption and
scattering (Arridge and Lionheart 1998). is makes it unfea-
sible, at present, to develop an “absolute” image reconstruction
scheme that can predict and account for both scattering and
absorbing baseline heterogeneities in tissue using LOT.
18.4 Optical Property and Basic
Geometry Determination
An a