Handbook of Biomedical Optics

712 Handbook of Biomedical Optics

Photothermal therapy has been demonstrated using nanorods

(Huang et al. 2006), nanoshells (Hirsch et al. 2003), nano-

cages (Au et al. 2008), and aggregates of nanospheres (Larson

et al. 2007, Zharov et al. 2005). e rst in vivo demonstration

involved the use of gold nanoshells that were injected into a

mouse xenogra tumor and CW NIR irradiation combined with

the use of MRI for temperature monitoring (Hirsch et al. 2003).

Tumor sites treated with nanoshells showed a maximum 34°C

increase in temperature (Figure 32.17a), while the saline control

showed a 13°C temperature increase as seen in Fig ...