Handbook of Biomedical Optics

756 Handbook of Biomedical Optics

caused by either light or by hydrogen peroxide was blocked by

the addition of antioxidants suggesting that light produces

ROS that then activates NF-B. e panoply of genes that are

responsive to NF-B include many involved in cell survival,

proliferation, migration, and collagen synthesis that adds fur-

ther weight to the hypothesis that some LLLT cell eects are

mediated by ROS-induced activation of NF-B (Chen et al.

2009b).

35.3.3 Downstream Cellular Effects

Although the underlying mechanisms of LLLT are still not

clearly understood, in vitro studies and both animal experi-

ments and cli ...