Handbook of Biomedical Optics

728 Handbook of Biomedical Optics

its SERS spectrum is signicantly narrower (<0.5 nm or 3 cm

−1

halfwidth). In a typical Raman spectrum, a spectral interval of

3000 cm

−1

can provide 3000/3 or 10

3

available individual spectral

“intervals” at any given time. Even allowing a reduction factor of

10 due to possible spectral overlaps, it should be possible to nd

dozens to 100 labels that can be used for labeling multiple probes

simultaneously. is multiplex advantage unique to Raman/

SERS is extremely important for ultra-high-throughput analy-

ses where multiple gene targets need to be screened in a highly

parallel multiplex modality.

33.5 Concl ...