Handbook of Biomedical Optics

Functional Optical Coherence Tomography in Preclinical Models 291

tissue simulating phantoms at 1310 nm (time-domain system

with 50 nm bandwidth with a 15 m spot size on the sample)

(Agrawal et al. 2006). e eect of nanoshell concentration, core

diameter, and shell thickness on signal enhancement was char-

acterized. Experimental results indicated trends that were con-

sistent with predicted optical properties, including a monotonic

increase in signal intensity and attenuation with increasing shell

and core size. reshold concentrations for a 2 dB OCT signal

intensity gain were determined for several nanoshell geometries.

Increases in t