
388 Handbook of Biomedical Optics
from conventional image reconstruction to MSIR. is requires
large memory capabilities and methods to reduce and optimize
this requirement are needed for successful volumetric imaging.
Several approaches have been used to counter this. One such
method is based on storing the Jacobian as a sparse matrix. is
is accomplished by setting a threshold on the Jacobian values,
below which the elements of the matrix are set to zero. Figure
19.13 shows a plot of the Jacobian, and from the gure it is obvi-
ous that a large portion of the Jacobian has low sensitivity val-
ues, which do not contribute much information rega ...