
Optical Coherence Tomography: Clinical Applications 313
18 patients with, and 22 individuals without suspicion of celiac
disease were imaged with OCT and the imaged locations were
subsequently biopsied for histopathologic analysis. Blinded
interpretation of the villi morphology in the OCT images and
in the histology slides was identical in all samples (Testoni et al.
2007). e promising results from this pilot study indicate that
OCT imaging of the duodenum may aid in the detection and
diagnosis of celiac disease. In addition, comprehensive large area
OCT imaging of the duodenum may reduce the large sampling
error associated with the