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9.1 Introduction
Diuse optical spectroscopy (DOS) employs model-based pho-
ton-migration methods to quantitatively separate light absorp-
tion spectra from scattering spectra in multiple scattering thick
tissues. Diuse optical spectroscopic imaging (DOSI) extends
this technology to an imaging format in order to map spectra
from discrete regions of tissue. Bandwidth is achieved by com-
bining time-independent spectroscopy with frequency-domain
photon migration (FDPM), reducing dependence on the avail-
ability of specic diode lasers while expanding spectral content to
hundreds of near-infrared (NIR) wavelengths (600–1000 nm).
is combined ...