Pharmaceutical Analysis

Chapter 1

Solubility Determinations

INTRODUCTION

Solubility is defined as the amount of substance dissolved in a given quantity of solvent. This is the main basis for the development of different branches of science such as chemistry, physics, and food science, and pharmaceutical and biological sciences. Especially in pharmaceutical science, it is most important because the bioavailability of the drug depends mainly on the solubility. This solubility phenomenon mainly helps in

• Selecting the appropriate solvent
• Overcoming the problems arising during preformulation
• Providing intermolecular forces of the drug

For the solubility phenomenon, the following terms are generally used:

• Solute: the substance which is dissolved in the solvent.
• Solvent ...