Pharmaceutical Analysis

Chapter 5

Analysis of Local Anaesthetic Drugs

Local anaesthetics are the drugs used for the anaesthetic effect on the local area. The commonly employed drugs are as follows:

• Benzocaine
• Procaine
• Cocaine
• Orthocaine

The following are analytical methods used for the determination of the drugs. They are as follows:

1. Spectrometric methods
   • Visible method
   • UV method
   • Fluorimetry
2. Titrimetric methods
   • Residual titration
   • Bromimetry
   • Precipitate titration
   • Titration with acid dyes
   • Gravimetry
3. IP methods

1. Spectrometric methods:
   1. Visible method:
      1. Diazotization method: Sample is mixed with HCl and NaNO₂ which act as diazotizing reagents. Then keep the solution a side for 3 min. Then add 95% alcohol and add coupling reagent such as 0.1% Bartton–Marshall reagent. ...