Pharmaceutical Analysis

Chapter 7

Vapour Phase Chromatography

INTRODUCTION

Vapour phase chromatography (VPC) is an advanced technique similar to gas chromatography. But it differs from the gas chromatography as both the stationary phase and mobile phase are gases in gas chromatography.

In conventional VPC, there is a stationary liquid/solid phase (generally high boiling liquid coated upon an inert granulated support) and a mobile gas phase, and the relative different interaction of the components of the mixture with these two phases result in desired separation. The stationary phase is liquid which is converted to vapour by increasing the temperature gradient moves in opposite direction that is to the gaseous phase. The main difference between the gas chromatography ...