Pharmaceutical Analysis

Chapter 5

Analysis of Amides

INTRODUCTION

The most of the pharmaceutical agents contain the amides. The amides containing drugs are the following: diazepam, thalidomide, barbiturates, nicotinamide, penicillins, sulfonamides, folic acid, etc.

Based on the importance of these drugs, the analytical methods are proposed. They are as follows:

• IR method: The IR method is mainly based on the measurement and interpretation of the absorbed IR radiation by the sample molecule which is observed by the stretching of the N–H stretching which shows the absorption maxima of 5.90–6.10 μm.
• UV method: This method is mainly based on the determination of the UV radiation absorption by the sample which undergoes transition. This is carried out by dissolving the ...