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Pharmaceutical Analysis by P. D. Chaithanya Sudha

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Chapter 4

2,4,6-Tripyridyl-S-Triazine (TPTZ)

INTRODUCTION

2,4,6-Tripyridyl-S-triazine (TPTZ) is the most widely used analytical regent for the spectrophotometric determination of phenols, phonetic drugs which easily undergoes exudation under experimental conditions. It is widely used for the determination of Iron.

STRUCTURE

 

2,4,6-Tripyridyl triazine

 

2,4,6-Tripyridyl triazine

PROCEDURE FOR DETERMINATIONS

The drug solution is heated with solution of ferric chloride and TPTZ at 100 °C for a period of 15 min.

MECHANISM OF ACTION

Under the proposed experimental conditions, the FeCl3 oxidised the drug and itself converted to ferrous [Fe+2] which forms a complex with TPTZ ...

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