Pharmaceutical Analysis

Chapter 8

Analysis of Sulphonamides

These compounds are mainly composed of amino group and the sulphonamide group. The general formula of sulphonamides is as follows:

 

R₁NHC₆H₄SO₂NR₂R₃

 

These are commonly used as antibiotics. This group of compounds are mainly analysed based on the aromatic amino group or the acidic hydrogen in the molecule, that is, the aromatic amino group is diazotised or titrated in non-aqueous medium and the acidic hydrogen is titrated with base in non-aqueous medium.

These compounds are generally analysed by the following:

• Titrimetric methods
• Spectrometric methods
• Chromatographic methods
• Salt formation
• Electro-analytical methods

1. Diazotisation titration: Diazotisation is the reaction where an aromatic amine reacts with ...