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Pharmaceutical Analysis
book

Pharmaceutical Analysis

by P. D. Chaithanya Sudha
July 2012
Intermediate to advanced content levelIntermediate to advanced
758 pages
17h 12m
English
Pearson India
Content preview from Pharmaceutical Analysis

Chapter 12

Size Exclusion Chromatography

INTRODUCTION

Size exclusion chromatography (SEC) was first developed by Lathe and Ruthven in 1955. In 1959, Porath and Flodin described the separation of the macromolecules on cross-linked poly dextrane gels. J.C. Moore of Dow Company proposed the separation of the synthetic polymers on cross-linked polystyrene gels in organic mobile phases. This method is the chromatographic method in which the molecules are separated based on the size. SEC is also called as gel permeation chromatography (GEC) and gel filtration chromatography. The separation of the biomolecules in aqueous or organic mobile phase is called as the gel filtration chromatography. The separation of the organic polymers in non-aqueous mobile ...

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Publisher Resources

ISBN: 9789332515659