Pharmaceutical Analysis

Chapter 6

Mass Spectrometry

INTRODUCTION

Wein in 1898 proposed first crude mass spectra and identified the two neon isotopes by mass spectrometry by combining the electrostatic and magnetic fields. Aston developed mass spectra for more than 50 elements. Beynon in 1960 first wrote on the theory of mass spectrometry. Dampster proposed the instrumentation for the mass spectroscopy.

Mass spectrometry is defined as the measurement and interpretation of the positive ions based on their masses. It gives the information about the molecular structure of the organic and inorganic compounds.

PRINCIPLE

The basic principle involved in mass spectroscopy is when the compounds are bombarded with electrons, the compound may lose one electron and forms metastable ...