Pharmaceutical Analysis

Chapter 2

Analysis of Antimalarials

DEFINITION

Antimalarials are the agents which are used for the treatment of malaria.

Chemical classifcation of antimalarials:

1. Cinchona alkaloids.

   Example: Quinine, quinidine, cinchonine.

2. 7-Chloro-4-amino quinolines.

   Example: Chloroquine, amodiaquine.

3. 9-Amino acridines.

   Example: Acridine, aciquine.

4. 8-Amino quinolines.

   Example: Primaquine, pentaquine.

5. 5-Antifolates.

   Example: Nitroguanil, pyrimethamine.

6. Sulphonamides.

   Example: Sulphodoxine, sulphadiazine.

7. Sulphones.

   Example: Dapsone.

8. Dihydrotriazines.

   Example: Cycloguanil.

9. Tetracyclines.

   Example: Chlortertracycline.

10. Anti-fungal agents.

    Example: Ketaconazole, mecanazole.

11. Oxidant drugs.

    Example: Sesiqueterpeneoxides or ketones.

Analytical methods available for ...