People with mobility disabilities are unable, to some extent, to perform fine motor actions with a mouse. They may have problems selecting small links and other targets or interacting with moving elements. They may tire easily.
Depending on the severity of the disability, people may interact with a keyboard, pointing devices such as head wands or mouth sticks, foot pedals, or they may use voice recognition software. These options should be supported.
For fatigue, provide ways of avoiding lengthy content, or skipping through content quickly.