November 2018
Beginner to intermediate
260 pages
5h 10m
Japanese
book
バイオビルダー ―合成生物学をはじめよう
by Natalie Kuldell, Rachel Bernstein, Karen Ingram, Kathryn M. Hart, 津田 和俊, 片野 晃輔, 西原 由実, 濱田 格雄
Content preview from バイオビルダー ―合成生物学をはじめよう
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133
のくらいうまく予測できるのかを問うものです。次に説明する遺伝子発現、プロモー
ターとリボソーム結合部位のパーツの役割についての理解は、演習を始めるために不
可欠です。
プロモーターと RBS
しばしば遺伝子発現の「セントラルドグマ」と呼ばれ、「
DNA
は
RNA
になり、
RNA
はタンパク質になる
（
DNA makes RNA makes protein
）
」という決まり文句は、タンパク質
が
RNA
配列の翻訳によって組み上がり、そして
RNA
配列が
DNA
配列から転写される
という教
義を短縮表現したものです
［
P.56
図
3-8
参照］
。タンパク質は細胞内で多くの重
要な仕事をしていて、転写と翻訳は細胞の振る舞いや形質の多くを制御します。それ
から驚くまでもなく、転写と翻訳はこれまで広く研究されており、遺伝子発現を制御
するために必要十分な、多くの中心的構成要素が知られています
（図
7-3
）
。
転写において「プロモーター」は特定の
DNA
配列のことを指し、そこに多タンパク
質の複合体である酵素の
RNA
ポリメラーゼが結合することで、
DNA
鋳型から
RNA
鎖
の形成が開始されます。翻訳において開始部位は、「リボソーム結合部位」
（
RBS
）
と
呼ばれます。なぜなら、リボソームは、この配列を認識し、
RNA
鋳型からタンパク質
の合成を開始するからです。これらの配列は、自然に起こる転写と翻訳の制御におい
て大きな役割を担っており、合成生物学者もそれらを使って、独自の制御の設計を導
入することができます。研究者は、既知のさまざまなプロモーターと ...
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I'm always learning. So when I got on to O'Reilly, I was like a kid in a candy store. There are playlists. There are answers. There's on-demand training. It's worth its weight in gold, in terms of what it allows me to do.