November 2018
Beginner to intermediate
260 pages
5h 10m
Japanese
book
バイオビルダー ―合成生物学をはじめよう
by Natalie Kuldell, Rachel Bernstein, Karen Ingram, Kathryn M. Hart, 津田 和俊, 片野 晃輔, 西原 由実, 濱田 格雄
Content preview from バイオビルダー ―合成生物学をはじめよう
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183
パーツとデ バイス
BioBuilder
の「
What a Colorful World
」実験演習では、ヴィオラセインのシステム
からの構成要素を使います。これは、遺伝子に比較的小さな改変をすることによって、
緑あるいは紫の色素が生成できます。通常、この色素生成システムへのインプットは
アミノ酸のトリプトファンであり、
5
つの酵素の作用
（
VioA
、
VioB
、
VioC
、
VioD
、
VioE
であ
るけれど、経路ではこの順序ではありません！）
によって、ヴィオラセインという紫の色素が
生成されます。しかし、
VioC
遺伝子が取り除かれると、経路の分岐はブロックされて
しまい、ヴィオラセインへの最終的な変換が起こりません。そのかわりにシステムの
終点は、プロトヴィオラセイン酸という濃い緑色の色素になります。この代謝経路
（図
ファル ネ シ ル 二リン 酸
crtE
crtYB
vioB
vioA
vioE
vioC vioD
vioC
crtI
crtI
crtYB
L-
トリプ トファン
インドー ルピ ルビン 酸
イミン
インドー ルピ ルビン 酸
イミンダ イマ ー
プ ロトデ オキシ
ヴィオラ セ イン 酸
デ オキシ ヴィオラセイン
プ ロトヴィオラ セイン 酸
ヴィオラ セ イン
ゲラニ ル 二リン 酸
フ ィト エ ン
ノイロスポレン
リコピン
β
-カロテン
［図9-6］色素生成の代謝経路。左側がカロテノイド、右側がヴィオラセインの経路である。ひし形はそれぞれの中間体
を、円は化学反応を担う酵素を示している。色の付いた化合物には、実物に近い色が反映 ...
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I wanted to learn C and C++, but it didn't click for me until I picked up an O'Reilly book. When I went on the O’Reilly platform, I was astonished to find all the books there, plus live events and sandboxes so you could play around with the technology.Addison B.
I’ve been on the O’Reilly platform for more than eight years. I use a couple of learning platforms, but I'm on O'Reilly more than anybody else. When you're there, you start learning. I'm never disappointed.Amir M.
I'm always learning. So when I got on to O'Reilly, I was like a kid in a candy store. There are playlists. There are answers. There's on-demand training. It's worth its weight in gold, in terms of what it allows me to do.