Polymer prodrug is a conjugation of a drug with a polymer form – a so-called “polymeric prodrug.” A prodrug is a form of a drug that remains inactive during its delivery to the site of action and then is activated by the specific conditions at the targeted site. In other words, a prodrug is an inactive precursor of a drug. The concept of the prodrug was first suggested by Albert and Harper.
In 1975 Prof. H. Ringsdorf developed a rational model (Figure 167.1) of a polymeric prodrug for the first time.
There are many ways to link the drug to the polymer. Figure 167.2 schematically illustrates the polymer prodrug synthesis.
Figure167.1 Ringsdorf’s model of a polymeric prodrug.
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