July 2024
Intermediate to advanced
280 pages
12h 52m
English
Content preview from The Essential Handbook of Polymer Terms and Attributes
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170 Polymer Therapeutic
Polymer therapeutic refers to nano-sized (5–100 nm) polymer-based pharmaceuticals. It includes rationally designed macromolecular drugs, polymer-drug and polymer-protein conjugates, polymeric micelles containing covalently bound drug, and polyplexes for DNA delivery.
Applications:
Currently, the major uses of polymer therapeutics are drug targeting delivery and controlled release.
Drug toxicity can be reduced by increasing the drug solubility through conjugation of a hydrophilic polymer scaffold to the drug in question. With conjugation to a polymer, drugs can also be protected from degradation, resulting in improved efficacy due to increased drug circulation times.
The tunable and responsive ...
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